🏆 Best Paper Award · Social Sim @ COLM 2026

PSI-Bench: Interpretable and Clinically Meaningful Evaluation of Depression Patient Simulators

Nguyen Khoi Hoang1,2 Shuhaib Mehri1 Tse-An Hsu1 Yi-Jyun Sun1 Quynh Xuan Nguyen Truong3 Khoa D. Doan2 Dilek Hakkani-TĂĽr1

1University of Illinois Urbana-Champaign 2VinUni-Illinois Smart Health Center 3College of Health Sciences, VinUniversity

Patient-SImulator-Bench (PSI-Bench) evaluates how realistically LLMs simulate patients with depression, using dimensions motivated by psycholinguistic research and comparisons with expert-curated depression-related conversations (Eeyore).

PSI-Bench Leaderboard

Scores are on a 0–100 scale, where higher means closer to human patients. Rank is assigned by Overall score (highest first), which is the average of the five dimension scores. For each column, Bold marks the best result and underlined the second best. Click a column header to sort by that dimension, and click row(s) to highlight those simulator settings in every per-dimension chart below.

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Evaluation Dimensions

Narrative-Emotion Processes (NEP) Markers

NEP Markers capture how patients express narrative content and emotional experience in psychotherapy, and how they evolve over a session reflects therapeutic progress. Each patient turn is classified as Problem (repetitive, “stuck” storylines with limited reflection), Transition (more coherent, reflective storytelling) or Change (clear shifts in emotion and thought, showing new understanding).

Population-level progression of NEP markers of patient responses across turns. Each panel shows the percentage of patient turns assigned to that marker at each of the first 16 turns, pooled across all patient profiles.

Emotional Valence

Depression is often associated with more negative and fewer positive emotion words, so we test whether simulated patients express and shift emotional valence over a conversation similar to how human patients do. Each patient message is classified as Negative, Positive or Neutral.

Population-level progression of emotional valence of patient responses across turns. Each panel shows the percentage of patient messages with that valence at each of the first 16 turns, pooled across all patient profiles.

Lexical Diversity

Patients with depression often show repetitions in words or ideas, whereas LLMs tend to generate highly diverse text. We examine how lexical diversity varies across human patients and whether a simulator conditioned on different profiles mirrors such variation. Each conversation is evaluated with the Measure of Textual Lexical Diversity (MTLD) over all of its patient messages concatenated.

Boxplots of lexical diversity of patient messages across conversations. Each box shows the spread of per-conversation MTLD across patient profiles for one setting (higher is more diverse). The dashed line marks the human median.

Response Length

Patients with depression tend to give short replies with limited content, while LLMs tend to be verbose. We measure response length via the average number of words per message and words per sentence.

The top charts show average words per message and per sentence at each turn, and the bottom charts show each setting's overall averages.

Linguistic Markers of Depression

Patients with depression tend to use more absolutist terms (e.g. “always”, “never”), depressive words tied to low mood and hopelessness, and non-fluencies (hesitations and fillers) that may signal cognitive or emotional strain. These markers enable a structured comparison of depressive linguistic tendencies between humans and simulators.

The tabs switch between all markers combined and each marker type. Rate is the number of markers per 1,000 tokens, and Prevalence is the percentage of messages containing at least one marker.

Evaluated Models / Method

Most simulator settings pair a simulator method with an assistant model as the backend LLM. The paper abbreviates each setting as the method's abbreviation followed by the model's, so . We do not apply Roleplay-doh to user models because its critique-and-refine pipeline introduces additional instruction-following requirements that may not align with their intended user simulation design. For Persimmon, we directly adopt the implementation provided by Humans&, without applying PATIENT-Ψ on top.

Citation

If you find PSI-Bench useful, please cite our paper:

@article{hoang2026psi,
  title={PSI-Bench: Towards Clinically Grounded and Interpretable Evaluation of Depression Patient Simulators},
  author={Hoang, Nguyen Khoi and Mehri, Shuhaib and Hsu, Tse-An and Sun, Yi-Jyun and Truong, Quynh Xuan Nguyen and Doan, Khoa D and Hakkani-T{\"u}r, Dilek},
  journal={arXiv preprint arXiv:2604.25840},
  year={2026}
}